In The News.
All Coverage →Nature Scientific Reports
Microscale fluid mechanics for next-generation sequencing library preparation
Aug 2025
Brown Engineering
Alejandra Hernandez-Moyers awarded Susan Pilch Friedman Excellence Award
Jul 2025
Cellular & Molecular Bioengineering
Fully automated, enzyme-free tissue dissociation method published
Aug 2025
IEEE BioSensors
Bioimpedance spectroscopy for glioblastoma spheroid characterization
Oct 2024
ACS Publications
Microfluidic characterization of mRNA and pDNA lipid nanoparticles
May 2024
The Analyst
Detection of dsRNA contaminants in mRNA vaccines via microfluidic electrophoresis
Jan 2024
Wiley Analytical Science
Assessment of plasmid DNA isoforms by microfluidic electrophoresis
Apr 2024
Biology Methods & Protocols
Cell2Read: automated workflow for sequencing-ready DNA library prep
Aug 2025
Brown University · School of Engineering
The Tripathi Lab develops microfluidic technologies that automate and accelerate molecular biology — from single-cell dissociation to sequencing-ready libraries.
Research
What we work on.
biology
Electric-Field Tissue Dissociation
Enzyme-free dissociation that applies tunable oscillating electric fields to release high-yield, viable single cells from intact tissue while preserving native cellular states.
innovation
Lab Automation & Instrumentation
Instruments that close the gaps in walk-away sample prep — including a compact, plug-and-play centrifuge engineered to drop into any liquid-handling robot.
biology
Single-Cell & Multi-Omic Assays
Automated workflows that turn dissociated cells into sequencing-ready libraries — and the assays that quantify how sample prep shapes viability, population representation, and molecular integrity.
biology
Organoid & 3D Culture Development
Reproducible spheroid and organoid models that recreate tissue architecture and disease progression — including endometrial organoids developed with Brown's Desai Lab.
microfluidics
mRNA Vaccines & Lipid Nanoparticles
Microfluidic-electrophoresis assays that flag residual dsRNA impurities in mRNA therapeutics and characterize the size, charge, and loading of lipid-nanoparticle delivery vehicles.
microfluidics
AAV & Gene-Therapy Characterization
Microfluidic electrophoresis that separates full from empty adeno-associated virus capsids and resolves serotype-level differences — quality metrics central to gene-therapy manufacturing.
innovation
Point-of-Care Diagnostics
Low-cost, minimal-equipment diagnostic workflows — dried-blood-spot nucleic-acid extraction, capillary plasma separation, and direct RT-PCR for use far from a central lab.
microfluidics
Liquid Biopsy & Cell-Free DNA
High-purity microfluidic extraction and size-based separation of cell-free DNA from plasma — enabling non-invasive prenatal testing, aneuploidy screening, and emerging liquid-biopsy assays.